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10.1136/gutjnl-2013-305112 27

Alcohol and smoking may increase oxidative stress and may reduce the expected benefit of treatment

Beyond metformin and rapamycin, emerging evidence suggests that selective autophagy modulators may benefit T2D-associated cognitive impairment

Presl), Poria (the dried sclerotia of Poria cocos (Schw.) Wolf), Moutan Cortex (the dried root bark of Paeonia x suffruticosa Andrews [Paeoniaceae]), Persicae Semen (the dried mature seed of Prunus persica (L.) Batsch [Rosaceae]) and Paeoniae Radix Alba (the dried root of Paeonia lactiflora Pall [Paeoniaceae]) ( The mechanism of GZFLW in inhibiting the proliferation and the induction of apoptosis has not been clearly defined

Furthermore, as described by Zimmerman et al, (29), ATP serves as a cofactor for signal transduction reactions using a variety of kinases as well as adenyl cyclase